Study on Phenotypical Activity of Isoenzyme CYP3A4 in Children
The urine levels of cortisol and 6-β-hydroxycortisol in 30 healthy children were determined with high performance liquid chromatography. The activity of cytochrome P450 isoenzyme CYP3A4 was estimated by the ratio of 6-β-hydroxycortisol and cortisol. Differences in the CYP3A4 activity depended on the...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
LLC "Publishing House OKI"
2020-05-01
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| Series: | Антибиотики и Химиотерапия |
| Subjects: | |
| Online Access: | https://www.antibiotics-chemotherapy.ru/jour/article/view/418 |
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| Summary: | The urine levels of cortisol and 6-β-hydroxycortisol in 30 healthy children were determined with high performance liquid chromatography. The activity of cytochrome P450 isoenzyme CYP3A4 was estimated by the ratio of 6-β-hydroxycortisol and cortisol. Differences in the CYP3A4 activity depended on the age sex. At the age of 4 to 9 years the value of the ratio was 9.21+0.67 which in fact was statistically higher than that in the children at the age of 0 to 3 years (p |
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| ISSN: | 0235-2990 |