KU124 (9,10,10-trioxo-N-(2-phenylphenyl)thioxanthene-3-carboxamide) as a novel inhibitor of TASK-1

KU124 (9,10,10-trioxo-N-(2-phenylphenyl)thioxanthene-3-carboxamide) as a novel inhibitor of TASK-1

TASK-1 is a two-pore K+ leak channel. The name, TASK-1, stands for TWIK-related acid-sensitive potassium channel 1, and this channel is encoded by the KCNK3 gene. TASK-1 channels are expressed in humans and modulate cell excitability in excitable cells such as neurons, cardiomyocytes, and vascular s...

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Main Authors: Ana Dumani, Annette Jacob, Diego Chavez, Abena Amankwaa, Ramish Zahed, Martha Julemis, Hinaben Patel, Joana Lopez, Steven Almazan, Patrick Martins, Anthony Contreras, Sofiia Korotka, Gianna Kiszka, Alexander Aleynik, Justin Patino, David Graham, Megan Blaisdell, Youssef Elhowary, Shuayb Yousuf, Chelsea Pelley, Jenna Marciano, Jessica Best, Rhustie Valdizno, Nikki Mastrodomenico, Jonelle Brown, Sarah Schwartz, Irene Anin, Yara Farrag, Rinchu George, Gianna Medeiros, Sophia Lang, Marilyn Dennis, Oluwatoni Awoleye, Lamont Lee, Ericka Salgado, Diana Figueroa Chea, Thomas Walter Comollo
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Pharmacology
Subjects:
TWIK-related acid-sensitive potassium channel 1
virtual screening
inhibitor
KU124
molecular dynamics
thallium flux
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1577171/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1577171/full

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