Heterologous biosynthesis of cotylenol and concise synthesis of fusicoccane diterpenoids
A novel strategy for the synthesis of fusicoccane diterpenoids is reported. By harnessing the biosynthetic pathways of brassicicenes and fusicoccins, cotylenol was produced in an engineered Aspergillus oryzae strain. We further achieved the concise synthesis of three fusicoccane diterpenoids, includ...
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Beilstein-Institut
2025-07-01
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| Serier: | Beilstein Journal of Organic Chemistry |
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| Online adgang: | https://doi.org/10.3762/bjoc.21.111 |
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| author | Ye Yuan Zhenhua Guan Xue-Jie Zhang Nanyu Yao Wenling Yuan Yonghui Zhang Ying Ye Zheng Xiang |
| author_facet | Ye Yuan Zhenhua Guan Xue-Jie Zhang Nanyu Yao Wenling Yuan Yonghui Zhang Ying Ye Zheng Xiang |
| author_sort | Ye Yuan |
| collection | DOAJ |
| description | A novel strategy for the synthesis of fusicoccane diterpenoids is reported. By harnessing the biosynthetic pathways of brassicicenes and fusicoccins, cotylenol was produced in an engineered Aspergillus oryzae strain. We further achieved the concise synthesis of three fusicoccane diterpenoids, including alterbrassicicene E and brassicicenes A and R in 4 or 5 chemical steps from brassicicene I. This strategy lays the foundation for the preparation of fusicoccane diterpenoids and their analogues for biological studies. |
| format | Article |
| id | doaj-art-fe63ac5bb1eb433fb239470b86fef2ad |
| institution | Matheson Library |
| issn | 1860-5397 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Beilstein-Institut |
| record_format | Article |
| series | Beilstein Journal of Organic Chemistry |
| spelling | doaj-art-fe63ac5bb1eb433fb239470b86fef2ad2025-08-04T07:27:25ZengBeilstein-InstitutBeilstein Journal of Organic Chemistry1860-53972025-07-012111489149510.3762/bjoc.21.1111860-5397-21-111Heterologous biosynthesis of cotylenol and concise synthesis of fusicoccane diterpenoidsYe Yuan0Zhenhua Guan1Xue-Jie Zhang2Nanyu Yao3Wenling Yuan4Yonghui Zhang5Ying Ye6Zheng Xiang7State Key Laboratory of Chemical Oncogenomics, Shenzhen Key Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen 518055, P. R. China Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, P. R. China State Key Laboratory of Chemical Oncogenomics, Shenzhen Key Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen 518055, P. R. China Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, P. R. China Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, P. R. China Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, P. R. China Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, P. R. China State Key Laboratory of Chemical Oncogenomics, Shenzhen Key Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen 518055, P. R. China A novel strategy for the synthesis of fusicoccane diterpenoids is reported. By harnessing the biosynthetic pathways of brassicicenes and fusicoccins, cotylenol was produced in an engineered Aspergillus oryzae strain. We further achieved the concise synthesis of three fusicoccane diterpenoids, including alterbrassicicene E and brassicicenes A and R in 4 or 5 chemical steps from brassicicene I. This strategy lays the foundation for the preparation of fusicoccane diterpenoids and their analogues for biological studies.https://doi.org/10.3762/bjoc.21.111cotylenolfusicoccane diterpenoidsheterologous biosynthesisp450 oxidationsynthesis |
| spellingShingle | Ye Yuan Zhenhua Guan Xue-Jie Zhang Nanyu Yao Wenling Yuan Yonghui Zhang Ying Ye Zheng Xiang Heterologous biosynthesis of cotylenol and concise synthesis of fusicoccane diterpenoids Beilstein Journal of Organic Chemistry cotylenol fusicoccane diterpenoids heterologous biosynthesis p450 oxidation synthesis |
| title | Heterologous biosynthesis of cotylenol and concise synthesis of fusicoccane diterpenoids |
| title_full | Heterologous biosynthesis of cotylenol and concise synthesis of fusicoccane diterpenoids |
| title_fullStr | Heterologous biosynthesis of cotylenol and concise synthesis of fusicoccane diterpenoids |
| title_full_unstemmed | Heterologous biosynthesis of cotylenol and concise synthesis of fusicoccane diterpenoids |
| title_short | Heterologous biosynthesis of cotylenol and concise synthesis of fusicoccane diterpenoids |
| title_sort | heterologous biosynthesis of cotylenol and concise synthesis of fusicoccane diterpenoids |
| topic | cotylenol fusicoccane diterpenoids heterologous biosynthesis p450 oxidation synthesis |
| url | https://doi.org/10.3762/bjoc.21.111 |
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