Hepatotoxic effects of aristolochic acid: mechanisms and implications
Herbal plants that contain aristolochic acids (AAs) have been widely used for medicinal purposes for centuries. However, human exposure to AAs via herbal or dietary intake is thought to be a causative factor for aristolochic acid nephropathy (AAN), hepatotoxic effects, and carcinomas. At present, th...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Compuscript Ltd
2024-08-01
|
| Series: | Acta Materia Medica |
| Online Access: | https://www.scienceopen.com/hosted-document?doi=10.15212/AMM-2024-0023 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1839638081438744576 |
|---|---|
| author | Qian Zhang Jiayun Chen Hengkai He Wentong Zhao Yinkwan Wong Wenhui Li Sha Feng Bin Liu Jigang Wang Piao Luo |
| author_facet | Qian Zhang Jiayun Chen Hengkai He Wentong Zhao Yinkwan Wong Wenhui Li Sha Feng Bin Liu Jigang Wang Piao Luo |
| author_sort | Qian Zhang |
| collection | DOAJ |
| description | Herbal plants that contain aristolochic acids (AAs) have been widely used for medicinal purposes for centuries. However, human exposure to AAs via herbal or dietary intake is thought to be a causative factor for aristolochic acid nephropathy (AAN), hepatotoxic effects, and carcinomas. At present, the molecular mechanisms underlying AA-induced hepatotoxicity and carcinogenesis and the corresponding detoxification strategies are unclear. This review summarizes the exposure, absorption, distribution, metabolism, and excretion (ADME) process of AAs. Importantly, to more objectively determine the emerging correlation between AAs and liver cancer, this review summarizes the possible direct and indirect connections between AAs and liver cancer. In brief, this review comprehensively summarizes and analyzes the molecular mechanisms underlying AA-induced hepatotoxicity and carcinogenesis, as well as an assessment of current detoxification strategies. At the same time, a new view on the prevention and detoxification of AA-induced hepatotoxicity is proposed. Chinese medicines that contain AAs might induce liver cancer but this is a controversial notion. This review summarizes relevant views from the past and provides novel insight into AA-induced liver injury or cancer to lay the foundation for AA detoxification. |
| format | Article |
| id | doaj-art-fd51b08387d2472db45d24c63f09716f |
| institution | Matheson Library |
| issn | 2737-7946 |
| language | English |
| publishDate | 2024-08-01 |
| publisher | Compuscript Ltd |
| record_format | Article |
| series | Acta Materia Medica |
| spelling | doaj-art-fd51b08387d2472db45d24c63f09716f2025-07-05T16:00:06ZengCompuscript LtdActa Materia Medica2737-79462024-08-013334936210.15212/AMM-2024-0023Hepatotoxic effects of aristolochic acid: mechanisms and implicationsQian ZhangJiayun ChenHengkai HeWentong ZhaoYinkwan WongWenhui LiSha FengBin LiuJigang WangPiao LuoHerbal plants that contain aristolochic acids (AAs) have been widely used for medicinal purposes for centuries. However, human exposure to AAs via herbal or dietary intake is thought to be a causative factor for aristolochic acid nephropathy (AAN), hepatotoxic effects, and carcinomas. At present, the molecular mechanisms underlying AA-induced hepatotoxicity and carcinogenesis and the corresponding detoxification strategies are unclear. This review summarizes the exposure, absorption, distribution, metabolism, and excretion (ADME) process of AAs. Importantly, to more objectively determine the emerging correlation between AAs and liver cancer, this review summarizes the possible direct and indirect connections between AAs and liver cancer. In brief, this review comprehensively summarizes and analyzes the molecular mechanisms underlying AA-induced hepatotoxicity and carcinogenesis, as well as an assessment of current detoxification strategies. At the same time, a new view on the prevention and detoxification of AA-induced hepatotoxicity is proposed. Chinese medicines that contain AAs might induce liver cancer but this is a controversial notion. This review summarizes relevant views from the past and provides novel insight into AA-induced liver injury or cancer to lay the foundation for AA detoxification.https://www.scienceopen.com/hosted-document?doi=10.15212/AMM-2024-0023 |
| spellingShingle | Qian Zhang Jiayun Chen Hengkai He Wentong Zhao Yinkwan Wong Wenhui Li Sha Feng Bin Liu Jigang Wang Piao Luo Hepatotoxic effects of aristolochic acid: mechanisms and implications Acta Materia Medica |
| title | Hepatotoxic effects of aristolochic acid: mechanisms and implications |
| title_full | Hepatotoxic effects of aristolochic acid: mechanisms and implications |
| title_fullStr | Hepatotoxic effects of aristolochic acid: mechanisms and implications |
| title_full_unstemmed | Hepatotoxic effects of aristolochic acid: mechanisms and implications |
| title_short | Hepatotoxic effects of aristolochic acid: mechanisms and implications |
| title_sort | hepatotoxic effects of aristolochic acid mechanisms and implications |
| url | https://www.scienceopen.com/hosted-document?doi=10.15212/AMM-2024-0023 |
| work_keys_str_mv | AT qianzhang hepatotoxiceffectsofaristolochicacidmechanismsandimplications AT jiayunchen hepatotoxiceffectsofaristolochicacidmechanismsandimplications AT hengkaihe hepatotoxiceffectsofaristolochicacidmechanismsandimplications AT wentongzhao hepatotoxiceffectsofaristolochicacidmechanismsandimplications AT yinkwanwong hepatotoxiceffectsofaristolochicacidmechanismsandimplications AT wenhuili hepatotoxiceffectsofaristolochicacidmechanismsandimplications AT shafeng hepatotoxiceffectsofaristolochicacidmechanismsandimplications AT binliu hepatotoxiceffectsofaristolochicacidmechanismsandimplications AT jigangwang hepatotoxiceffectsofaristolochicacidmechanismsandimplications AT piaoluo hepatotoxiceffectsofaristolochicacidmechanismsandimplications |