Leptin: a gender and obesity-related marker predictive of metabolic comorbidities and therapeutic response to anti-IL-23 biologic drugs in psoriatic patients

Leptin: a gender and obesity-related marker predictive of metabolic comorbidities and therapeutic response to anti-IL-23 biologic drugs in psoriatic patients

IntroductionPsoriasis is a chronic immune-mediated inflammatory skin disorder, frequently associated with comorbidities such as obesity, which can exacerbate its severity and hinder treatment efficacy. Psoriasis pathogenesis involves complex interactions among genetic, environmental, hormonal factor...

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Main Authors: Roberta Belli, Anna Dattolo, Francesca Sampogna, Emanuela Gubinelli, Daniela Lulli, Gaia Moretta, Emanuele Scala, Luca Sanna, Matteo Megna, Maria Vittoria Cannizzaro, Melania Parisi, Cecilia Luordi, Claudia Scarponi, Maria Quaranta, Maria Grazia Lolli, Lorena Silvestri, Paolo Gisondi, Giampiero Girolomoni, Sabatino Pallotta, Cristina Albanesi, Laura Mercurio, Stefania Madonna
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Immunology
Subjects:
psoriasis
obesity
adipokines
anti-IL-17 biologics
anti-IL-23 biologics
gender
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1607312/full
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