Toxoplasma gondii virulence in mice is determined by the pseudokinase ROP5B and countered by an IRG-GBP protein interplay

Toxoplasma gondii virulence in mice is determined by the pseudokinase ROP5B and countered by an IRG-GBP protein interplay

Toxoplasma gondii (T. gondii) virulence in mice depends on different multiprotein complexes that assemble at the parasitophorous vacuole membrane (PVM) of the parasite. Individual rhoptry proteins within these complexes inhibit different Immunity-Related GTPases (IRG proteins). The rhoptry pseudokin...

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Bibliographic Details
Main Authors: Shishir Singh, Mateo Murillo-León, Aura María Bastidas Quintero, Florence Melbert, Klaus Pfeffer, Daniel Degrandi, Tobias Steinfeldt
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Immunology
Subjects:
host cell resistance
co-evolution
IRG/GBP proteins
T. gondii virulence
pseudokinases
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1593785/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1593785/full

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