Development of a Novel Drug Delivery System “Nanoemulfoam” for Topical Delivery of Terbinafine Hydrochloride as a Repurposed Therapy in Skin Cancer: Formulation, Optimization, In Vitro Characterization, Ex Vivo Transdermal Permeability, Cytotoxicity Studies, and In Silico Assessment

Development of a Novel Drug Delivery System “Nanoemulfoam” for Topical Delivery of Terbinafine Hydrochloride as a Repurposed Therapy in Skin Cancer: Formulation, Optimization, In Vitro Characterization, Ex Vivo Transdermal Permeability, Cytotoxicity Studies, and In Silico Assessment

<b>Background:</b> Skin cancer has become a global health issue because of increasing exposure to environmental contaminants and UV radiation. Terbinafine hydrochloride (TRB), a broad-spectrum antifungal medication, has demonstrated notable anti-tumor properties in previous studies; howe...

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Main Authors: Abeer A. Musallam, Reem A. Aldeeb, Riham M. Mansour, Manar Abd El-karim Kassem, Doaa Fayez Saeed, Mahmoud A. Mahdy, Rana M. Abdelnaby, Hanan M. Elnahas, Tarek M. Ibrahim
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Pharmaceuticals
Subjects:
terbinafine hydrochloride
nanoemulfoam
D-optimal design
drug repurposing
ex vivo permeation
cell viability
Online Access:https://www.mdpi.com/1424-8247/18/7/972
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