A comparison of viral strategies and model systems to target norepinephrine neurons in the locus coeruleus reveals high variability in transgene expression patterns.

The locus coeruleus (LC) norepinephrine (NE) system is involved in a variety of physiological and pathophysiological processes. Refining our understanding of LC function largely relies on selective transgene expression in LC-NE neurons, allowing targeted manipulation and readout of noradrenergic neu...

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Auteurs principaux: Chantal Wissing, Lena S Eschholz, Maxime Maheu, Kathrin Sauter, Fabio Morellini, J Simon Wiegert, Alexander Dieter
Format: Article
Langue:anglais
Publié: Public Library of Science (PLoS) 2025-07-01
Collection:PLoS Biology
Accès en ligne:https://doi.org/10.1371/journal.pbio.3003228
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