A high effective expression of human D-glucuronyl C5-epimerase with dimer structure in Escherichia coli

IntroductionHeparan sulfate (HS), a linear anionic polysaccharide, participates in many physiological processes and exhibits many pharmacological activities. D-glucuronyl C5-epimerase (Glce) is one of the key enzymes in the biosynthesis of heparan sulfate proteoglycans. However, the recombinant Glce...

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Bibliographic Details
Main Authors: Qin-xia Song, Li-jian Guo
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Microbiology
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Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2025.1641598/full
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