Epitope Variation in Hemagglutinin and Antibody Responses to Successive A/Victoria A(H1N1) Strains in Young and Older Adults Following Seasonal Influenza Vaccination: A Pilot Study

Epitope Variation in Hemagglutinin and Antibody Responses to Successive A/Victoria A(H1N1) Strains in Young and Older Adults Following Seasonal Influenza Vaccination: A Pilot Study

<b>Background:</b> Annual influenza vaccine updates target viral drift, but immune responses may be biased by original antigenic sin (OAS). Few studies have explored this across closely related strains. This study examines how OAS shapes responses to sequential influenza variants in the...

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Main Authors: Mónica Espinar-García, Isabel María Vallejo-Bermúdez, María Ángeles Onieva-García, Irene Reina-Alfonso, Luis Llapa-Chino, Pablo Álvarez-Heredia, Inmaculada Salcedo, Rafael Solana, Alejandra Pera, Alexander Batista-Duharte
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Vaccines
Subjects:
influenza vaccine
original antigenic sin (OAS)
antigenic imprinting
B-cell epitope mapping
hemagglutinin (HA)
immune response
Online Access:https://www.mdpi.com/2076-393X/13/7/774
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https://www.mdpi.com/2076-393X/13/7/774

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