The E3 ubiquitin ligase DTX3L and the deubiquitinase USP28 fine-tune DNA repair through mutual regulation of their protein levels

The E3 ubiquitin ligase DTX3L and the deubiquitinase USP28 fine-tune DNA repair through mutual regulation of their protein levels

Summary: The DNA damage response (DDR) relies on a complex protein network to maintain genomic integrity, yet the interplay between post-translational modifiers remains poorly understood. Here, we uncover a novel regulatory axis between the E3 ubiquitin ligase DTX3L and the deubiquitinase USP28 at D...

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Bibliographic Details
Main Authors: Daniela Mennerich, Yashwanth Ashok, Carlos Vela-Rodríguez, Heli I. Hentilä, Melanie Rall-Scharpf, Lisa Wiesmüller, Renata Prunskaite-Hyyryläinen, Lari Lehtiö, Thomas Kietzmann
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:iScience
Subjects:
Molecular biology
Cell biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004225012519
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http://www.sciencedirect.com/science/article/pii/S2589004225012519

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