Enzyme and cofactor engineering to increase d-xylonate dehydratase activity for improved d-1,2,4-butanetriol production from d-xylose

d-1,2,4-Butanetriol (BTO), a C4 platform compound, is widely used in fields such as military and pharmaceuticals. Biosynthesis of d-1,2,4-BTO from lignocellulose-derived d-xylose presents a promising production route. However, the low catalytic activity of d-xylonate dehydratase leading to the accum...

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Bibliographic Details
Main Authors: Jingwen Chen, Zhangyu Liu, Dandan Mai, Sheng Xu, Xin Wang, Kequan Chen
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2025-12-01
Series:Synthetic and Systems Biotechnology
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2405805X25001000
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