Effect of DNA target size on the efficiency of chimerism measurement in circulating free plasma DNA

Effect of DNA target size on the efficiency of chimerism measurement in circulating free plasma DNA

Introduction. The analysis of free circulating DNA (cfDNA) holds promise for molecular diagnostics, but its fragmentation and low concentration can complicate PCR analysis.Objective. To investigate the effect of target length on the amplification efficiency of Y-chromosome markers from cfDNA.Materia...

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Main Authors: E. E. Nikulina, N. V. Risinskaya, O. E. Dubova, O. V. Sumtsova, Ya. G. Moysyuk, V. A. Vasilieva, M. V. Soloveva, A. A. Yushkova, I. S. Fevraleva, A. S. Skripkina, A. A. Makarik, A. B. Sudarikov
Format: Article
Language:English
Published: N.V. Sklifosovsky Research Institute for Emergency Medicine of Moscow Healthcare Department 2024-12-01
Series:Трансплантология (Москва)
Subjects:
free circulating dna
target dna
chimerism
liver transplantation
allogeneic hematopoietic stem cell transplantation
pregnancy
Online Access:https://www.jtransplantologiya.ru/jour/article/view/939
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https://www.jtransplantologiya.ru/jour/article/view/939

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