Inhibiting miR-200a-3p Increases Sirtuin 1 and Mitigates Kidney Injury in a Tubular Cell Model of Diabetes and Hypertension-Related Renal Damage

Inhibiting miR-200a-3p Increases Sirtuin 1 and Mitigates Kidney Injury in a Tubular Cell Model of Diabetes and Hypertension-Related Renal Damage

Hypertension and diabetes mellitus are key contributors to kidney damage, with the renal tubule playing a central role in the progression of kidney disease. MicroRNAs have important regulatory roles in renal injury and are among the most abundant cargos within extracellular vesicles (EVs), emerging...

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Bibliographic Details
Main Authors: Olga Martinez-Arroyo, Ana Flores-Chova, Marta Mendez-Debaets, Laia Garcia-Ferran, Lesley Escrivá, Maria Jose Forner, Josep Redón, Raquel Cortes, Ana Ortega
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Biomolecules
Subjects:
biomarker
miR-200a-3p
renal damage
Sirtuin 1
tubular injury
extracellular vesicles
Online Access:https://www.mdpi.com/2218-273X/15/7/995
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