The mediation effects of white matter microstructural abnormalities on the associations between cerebral small vessel disease burden and cognitive impairment

The mediation effects of white matter microstructural abnormalities on the associations between cerebral small vessel disease burden and cognitive impairment

Background: White matter (WM) microstructural deterioration is associated with a higher total cerebral small vessel disease (CSVD) burden, as assessed by magnetic resonance imaging (MRI) markers, and with more pronounced cognitive decline in CSVD patients. However, the relationships among CSVD burde...

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Main Authors: Chaofan Sui, Changhu Liang, Yian Gao, Na Wang, Xinyue Zhang, Yuanyuan Wang, Nan Zhang, Yena Che, Mengmeng Feng, Haotian Xin, Jing Li, Lingfei Guo, Hongwei Wen
Format: Article
Language:English
Published: Elsevier 2025-10-01
Series:Neurobiology of Disease
Subjects:
Cerebral small vessel disease
Diffusion tensor imaging
White matter microstructure
Cognitive dysfunction
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996125002414
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http://www.sciencedirect.com/science/article/pii/S0969996125002414

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