TNF-α-preconditioning enhances analgesic efficacy of mesenchymal stem cell-derived extracellular vesicle in neuropathic pain via miR-101b-3p targeting Nav1.6

TNF-α-preconditioning enhances analgesic efficacy of mesenchymal stem cell-derived extracellular vesicle in neuropathic pain via miR-101b-3p targeting Nav1.6

Mesenchymal stem cell-derived extracellular vesicle (MSC-EV) has shown promise for pain relief, but its efficacy is limited. Preconditioning MSC with tumor necrosis factor-α (TNF-α) may enhance their therapeutic potential; however, the impact on analgesia and underlying mechanisms remains unclear. H...

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Bibliographic Details
Main Authors: Lanyu Zhang, Jinping Wang, Jin Liu, Juan Xin, Yuan Tan, Donghang Zhang, Tao Zhu, Cheng Zhou
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2025-11-01
Series:Bioactive Materials
Subjects:
Pain
Extracellular vesicle
MSC
Neuron
MicroRNA
Online Access:http://www.sciencedirect.com/science/article/pii/S2452199X25003226
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http://www.sciencedirect.com/science/article/pii/S2452199X25003226

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