Characterization of Parthanatos in Breast Cancer: Implications for Prognosis and PARP Inhibitor Resistance

Characterization of Parthanatos in Breast Cancer: Implications for Prognosis and PARP Inhibitor Resistance

Parthanatos, a novel form of programmed cell death mediated by PARP1 and driven by DNA damage, has not been comprehensively characterized in breast cancer (BC). Given the widespread clinical use of PARP1 inhibitors for treating BRCA-mutant breast cancers, understanding the role of parthanatos is cru...

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Bibliographic Details
Main Authors: Junjie Tang, Qian Liu, Wei Du, Linxi Chen, Feiyang Qi, Ranxin Zhang, Bang H. Hoang, David S. Geller, Rui Yang, Jichuan Wang, Li Hu
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Bioengineering
Subjects:
parthanatos
breast cancer
tumor immune microenvironment
single-cell sequencing
subtypes
Online Access:https://www.mdpi.com/2306-5354/12/6/586
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