Induction of proximal tubular proliferation and lengthening in response to sodium glucose linked cotransporter‐2 inhibition in experimental rats

Induction of proximal tubular proliferation and lengthening in response to sodium glucose linked cotransporter‐2 inhibition in experimental rats

ABSTRACT Aims/Introduction While SGLT2 accounts for >90% of kidney glucose reabsorption, its pharmacological inhibition or genetic knockdown reduces glucose reabsorption by only 50%. Materials and Methods We postulated that the less than expected glucosuric response to SGLT2 inhibition might resu...

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Main Authors: Ellen Wu, Sarah Macklin, Yanling Zhang, Kerri Thai, Linda Nghiem, Caterina Di Ciano‐Oliveira, Nuno Coelho, Hai Wang, Suzanne L. Advani, Jean‐François Desjardins, Darren A Yuen, Paraish Misra, Kim A. Connelly, Jens R. Nyengaard, Richard E. Gilbert
Format: Article
Language:English
Published: Wiley 2025-07-01
Series:Journal of Diabetes Investigation
Subjects:
Kidney growth
proximal kidney tubule
sodium‐glucose linked cotransporter 1, 2
Online Access:https://doi.org/10.1111/jdi.70043
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https://doi.org/10.1111/jdi.70043

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