The LATTICE Study: Design of a pilot feasibility randomized controlled trial of lithium to delay cognitive decline in mild cognitive impairment

The LATTICE Study: Design of a pilot feasibility randomized controlled trial of lithium to delay cognitive decline in mild cognitive impairment

Abstract INTRODUCTION Interest has grown in lithium's neuroprotective properties in neurodegenerative illnesses. We discuss the design, rationale, and implementation of a pilot feasibility, double‐blind, randomized placebo‐controlled trial (RCT) examining whether lithium can delay cognitive dec...

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Main Authors: Ariel G. Gildengers, Tamer S. Ibrahim, Xuemei Zeng, Howard J. Aizenstein, Salem K. Alkhateeb, Stewart J. Anderson, Cong Chu, Jihui L. Diaz, James E. Emanuel, Thomas K. Karikari, Jinghang Li, Oscar L. Lopez, Brian J. Lopresti, Sarah K. Royse, Andrea N. Sajewski, Tales Santini, Andrea M. Weinstein, Minjie Wu, Meryl A. Butters
Format: Article
Language:English
Published: Wiley 2025-04-01
Series:Alzheimer’s & Dementia: Translational Research & Clinical Interventions
Subjects:
Alzheimer's disease
clinical trial
lithium
mild cognitive impairment
neurocognitive assessment
neuroimaging
Online Access:https://doi.org/10.1002/trc2.70112
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https://doi.org/10.1002/trc2.70112

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