Liraglutide Attenuates Atorvastatin-Induced Hepatotoxicity by Restoring GLP-1R Expression and Activating Nrf2 and Autophagy Pathways in Wistar Rats

Liraglutide Attenuates Atorvastatin-Induced Hepatotoxicity by Restoring GLP-1R Expression and Activating Nrf2 and Autophagy Pathways in Wistar Rats

HMG-CoA reductase inhibitors, statins, are extensively used to treat hyperlipidemia, coronary artery disease, and other atherosclerotic disorders. However, one of the common side effects of statin therapy is a mild elevation in liver aminotransferases, observed in less than 3% of patients. Atorvasta...

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Bibliographic Details
Main Authors: Engy A. Elsiad, Hayat A. Abd El Aal, Hesham A. Salem, Mohammed F. El-Yamany, Mostafa A. Rabie
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Toxics
Subjects:
atorvastatin
liraglutide
hepatotoxicity
GLP-1R/Akt
autophagy
Online Access:https://www.mdpi.com/2305-6304/13/7/594
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