Anti‐PD‐1 therapy redirects macrophages from an M2 to an M1 phenotype inducing regression of OS lung metastases

Anti‐PD‐1 therapy redirects macrophages from an M2 to an M1 phenotype inducing regression of OS lung metastases

Abstract Osteosarcoma (OS) pulmonary metastasis translates into poor patient survival. The implication of PD‐1‐PD‐L1 pathway in the context of NK cells and/or macrophages in OS is unknown. We investigated the effect of anti‐PD‐1 in OS lung metastasis and the role of NK cells and/or macrophages in an...

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Bibliographic Details
Main Authors: Pooja Dhupkar, Nancy Gordon, John Stewart, Eugenie S. Kleinerman
Format: Article
Language:English
Published: Wiley 2018-06-01
Series:Cancer Medicine
Subjects:
Immunotherapy
lung metastasis
macrophages
osteosarcoma
programmed death ligand‐1
Online Access:https://doi.org/10.1002/cam4.1518
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https://doi.org/10.1002/cam4.1518

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