Impairment of regulatory T cell stability in axial spondyloarthritis: role of EZH2 and pSTAT5

Impairment of regulatory T cell stability in axial spondyloarthritis: role of EZH2 and pSTAT5

Background and objectivesAxial spondyloarthritis (axSpA) is a chronic inflammatory disease involving the spine, peripheral joints, and entheses. Functional impairment of regulatory T cells (Treg) is linked to inflammatory diseases, but limited data is available regarding Treg involvement in axSpA. T...

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Bibliographic Details
Main Authors: Majda Lyna Mebrek, Tessnime Abaab, Delphine Lemeiter, Magali Breckler, Roxane Hervé, Mylène Petit, Gaëlle Clavel, Johanna Sigaux, Marie-Christophe Boissier, Luca Semerano, Jérôme Biton, Natacha Bessis
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-11-01
Series:Frontiers in Immunology
Subjects:
regulatory T cells
spondyloarthritis
TNF inhibitors
EZH2
PSTAT5
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1484321/full
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