Regenerative Synergy: Combining Platelet-rich Plasma with Transcutaneous Temperature-controlled Radiofrequency for Enhanced Treatment of Stress Urinary Incontinence in Peri- and Postmenopausal Women
Background: Stress urinary incontinence (SUI) is a significant health concern among peri-and postmenopausal women, often leading to diminished quality of life. Transcutaneous temperature-controlled radiofrequency (TTCRF) has emerged as a minimally invasive treatment option, but its efficacy may be l...
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| Main Author: | |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2025-04-01
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| Series: | Journal of Mid-Life Health |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/jmh.jmh_34_25 |
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| Summary: | Background:
Stress urinary incontinence (SUI) is a significant health concern among peri-and postmenopausal women, often leading to diminished quality of life. Transcutaneous temperature-controlled radiofrequency (TTCRF) has emerged as a minimally invasive treatment option, but its efficacy may be limited in cases of severe tissue laxity. Platelet-rich plasma (PRP) offers a promising adjunct to enhance tissue remodeling and functional recovery when combined with TTCRF.
Objective:
This study evaluates the safety, efficacy, and patient-reported outcomes of combining PRP with TTCRF for treating SUI in peri- and postmenopausal women, aiming to address gaps in current therapeutic strategies.
Materials and Methods:
A prospective, randomized controlled trial was conducted involving 80 peri- and postmenopausal women diagnosed with SUI. Participants were randomly assigned to two groups: PRP plus TTCRF (intervention group, n = 40) and TTCRF alone (control group, n = 40). Primary outcome measures included objective improvement assessed via urodynamic studies and subjective improvement evaluated using validated questionnaires (International Consultation on Incontinence Questionnaire - Short Form [ICIQ-SF] and Urogenital Distress Inventory). Secondary outcomes encompassed quality of life (Pelvic Floor Distress Inventory [PFDI-20]) and adverse event reporting. Statistical analyses were performed using SPSS version 27.0, with significance set at P < 0.05.
Results:
At the 12-month follow-up, the intervention group demonstrated significantly superior outcomes compared to the control group. The mean reduction in ICIQ-SF scores was 9.8 points versus 6.6 points (P = 0.001), and urodynamic parameters improved by 32% more in the PRP plus TTCRF group (P = 0.003). Quality of life, as measured by PFDI-20, showed a 22% greater improvement in the intervention group (P = 0.002).
Conclusion:
Combining PRP with TTCRF represents an innovative, minimally invasive approach that enhances tissue regeneration and functional recovery in peri- and post-menopausal women with SUI. These findings highlight the potential of PRP to augment the efficacy of TTCRF and warrant further investigation in larger, multicenter trials. |
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| ISSN: | 0976-7800 0976-7819 |