Indole-3-Carbinol Enhances Alternative Activation of Macrophages via AHR Pathway and Glucose Transporter Regulation

Indole-3-Carbinol Enhances Alternative Activation of Macrophages via AHR Pathway and Glucose Transporter Regulation

Disruption in macrophage polarization is linked to inflammatory diseases and metabolic disorders. Our study aimed to investigate how AHR activation by I3C and TCDD could impact glucose transporters and macrophage phenotypes and functions in human macrophages. Human monocyte-derived macrophages (hMDM...

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Bibliographic Details
Main Authors: Delara Omrani, Saeed Mohammadi, Moein Malekzadeh, Mohsen Saeidi, Fakhri Sadat Seyedhosseini, Ahmed Al-Harrasi, Yaghoub Yazdani
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Immuno
Subjects:
aryl hydrocarbon receptor (AHR)
indole-3-carbinol (I3C)
TCDD
LPS
macrophage polarization
M2 macrophages
Online Access:https://www.mdpi.com/2673-5601/5/2/15
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