Astragalus polysaccharides protect against Di-n-butyl phthalate-induced testicular damage by modulating oxidative stress, apoptosis, and the PI3K/Akt/mTOR pathway in rats

Astragalus polysaccharides protect against Di-n-butyl phthalate-induced testicular damage by modulating oxidative stress, apoptosis, and the PI3K/Akt/mTOR pathway in rats

IntroductionDi-n-butyl phthalate (DBP), a common plasticizer, is associated with oxidative stress and male reproductive toxicity. Astragalus polysaccharides (APS) have known antioxidative and anti-inflammatory properties, but their role in male reproductive health has not been fully elucidated.Metho...

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Bibliographic Details
Main Authors: Manal R. Bakeer, Seham Samir Soliman, Omaima Ahmed, Fady Sayed Youssef, Ghada E. Ali, Nada H. Aljarba, George D. Zouganelis, Maha M. Rashad
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Veterinary Science
Subjects:
dibutyl phthalate
astragalus polysaccharides
oxidative stress
reproductive toxicity
apoptosis
PI3K/AKT/mTOR pathway
Online Access:https://www.frontiersin.org/articles/10.3389/fvets.2025.1616186/full
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