The Role of Fat Mass and Obesity-Associated (FTO) Gene in Non-Small Cell Lung Cancer Tumorigenicity and EGFR Tyrosine Kinase Inhibitor Resistance

The Role of Fat Mass and Obesity-Associated (FTO) Gene in Non-Small Cell Lung Cancer Tumorigenicity and EGFR Tyrosine Kinase Inhibitor Resistance

<b>Background/Objectives</b>: The fat mass and obesity-associated (FTO) protein demethylates nuclear N6-Methyladenosine (m6A) on mRNA, facilitates tumor growth, and contributes to therapeutic resistance in multiple cancer types. Recent evidence demonstrates several roles of FTO in tumori...

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Bibliographic Details
Main Authors: Aayush Rastogi, Rong Qiu, Rachel Campoli, Usama Altayeh, Sarai Arriaga, Muhammad J. Khan, Subaranjana Saravanaguru Vasanthi, Robert Hillwig, Neelu Puri
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Biomedicines
Subjects:
fat mass and obesity-associated gene (FTO)
EGFR TKI resistance
non-small cell lung cancer (NSCLC)
N6-Methyladenosine (m6A)
late stage
smokers
Online Access:https://www.mdpi.com/2227-9059/13/7/1653
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