Temperature and WNK-SPAK/OSR1 Kinases Dynamically Regulate Antiviral Human GFP-MxA Biomolecular Condensates in Oral Cancer Cells

Temperature and WNK-SPAK/OSR1 Kinases Dynamically Regulate Antiviral Human GFP-MxA Biomolecular Condensates in Oral Cancer Cells

Phase-separated membraneless biomolecular condensates in the cytoplasm and nucleus are now recognized to play a major role in modulating diverse functions in mammalian cells, and contribute to cancer pathogenesis through dysregulated function of condensates of transcription factors such as STAT3 and...

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Bibliographic Details
Main Authors: Pravin B. Sehgal, Huijuan Yuan, Susan V. DiSenso-Browne
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Cells
Subjects:
pathogenesis of oral cancer
anatomical sites of oral cancer
hypotonic and temperature stresses
structure of biomolecular condensates
human myxovirus resistance protein (MxA/Mx1)
WNK-SPAK/OSR1 kinases
Online Access:https://www.mdpi.com/2073-4409/14/13/947
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