Detection of Copy Number Variations from <i>HIF1A</i> and <i>HIF2A</i> Gene as Genetic Determinants of Bovine Carcass Traits

Detection of Copy Number Variations from <i>HIF1A</i> and <i>HIF2A</i> Gene as Genetic Determinants of Bovine Carcass Traits

The beef cattle industry has seen rapid expansion, necessitating the optimization of slaughter traits for enhanced economic benefits. Copy number variation (CNV) has emerged as a pivotal molecular marker in marker-assisted selection (MAS) for genetic improvement in livestock. In this study, we focus...

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Bibliographic Details
Main Authors: Enhui Jiang, Yingjie Zhou, Yunan He, Zhuoyuan He, Hongyang Wang, Leijing Zhu, Chuanying Pan, Chuzhao Lei, Fugui Jiang, Xianyong Lan
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Agriculture
Subjects:
beef cattle
<i>HIF1A</i>
<i>HIF2A</i>
CNV
carcass traits
Online Access:https://www.mdpi.com/2077-0472/15/12/1240
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Summary:The beef cattle industry has seen rapid expansion, necessitating the optimization of slaughter traits for enhanced economic benefits. Copy number variation (CNV) has emerged as a pivotal molecular marker in marker-assisted selection (MAS) for genetic improvement in livestock. In this study, we focused on CNVs within the <i>HIF1A</i> and <i>HIF2A</i> genes, which play crucial roles in hypoxic signaling and energy metabolism. Four CNVs were identified in the bovine <i>HIF1A</i> gene and three in <i>HIF2A</i> using the AAOD database. In Gaoqing Black cattle (GQB), the distribution of CNVs for both genes was investigated, revealing predominantly median copy numbers. Association analysis showed a significant relation between CNVs in <i>HIF1A</i> and carcass traits such as cervical vertebrae (CNV1), initial weight and beef diaphragm (CNV2), slaughter weight and chuck (CNV3), and femur and chuck (CNV4) (<i>p</i> < 0.05 or <i>p</i> < 0.01). Similarly, CNVs in <i>HIF2A</i> are associated with traits like beef diaphragm, beef knuckle bone, and beef tendon (CNV1), longissimus dorsi width and beef diaphragm (CNV2), and slaughter weight and limb weights (CNV3) (<i>p</i> < 0.05 or <i>p</i> < 0.01). These findings provide insights into the potential influence of CNVs in <i>HIF1A</i> and <i>HIF2A</i> on carcass traits in Gaoqing Black cattle, offering a theoretical basis for genetic improvement in beef cattle breeding.
ISSN:2077-0472

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