Factors determining the outcomes of immune imprinting after repeated orthoflavivirus infections

Orthoflaviviruses, a group of arthropod-borne viruses, represent a significant global health threat, with hundreds of millions of infections each year, often leading to severe clinical outcomes. This Review elucidates the complexities of immune imprinting, also known as original antigenic sin (OAS),...

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Bibliographic Details
Main Authors: Gielenny M. Salem, Fan-Chi Chen, James J. Cai, Day-Yu Chao
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Immunology
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1560851/full
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