Auranofin amplifies schisandrin A-induced apoptosis through ROS generation and inhibiting the PI3K/Akt pathway in hepatocellular carcinoma

Auranofin amplifies schisandrin A-induced apoptosis through ROS generation and inhibiting the PI3K/Akt pathway in hepatocellular carcinoma

Objective: To investigate the synergistic effects of auranofm and schisandrin A (SA) on cell proliferation inhibition and apoptosis induction in human hepatocellular carcinoma Hep3B cells. Methods: Cell viability was assessed using MTT to determine the synergistic effects of auranofin and SA. Three-...

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Main Authors: Hyun Hwangbo, Seon Yeong Ji, Min Yeong Kim, Su Hyun Hong, Sung Ok Kim, Gi-Young Kim, Yung Hyun Choi
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2025-06-01
Series:Asian Pacific Journal of Tropical Biomedicine
Subjects:
auranofin
apoptosis
hepatocellular carcinoma
reactive oxygen species
schisandrin a
pi3k/akt
Online Access:https://journals.lww.com/10.4103/apjtb.apjtb_83_25
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https://journals.lww.com/10.4103/apjtb.apjtb_83_25

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