Plant-derived extracellular vesicles as a natural drug delivery platform for glioblastoma therapy: A dual role in preserving endothelial integrity while modulating the tumor microenvironment
Glioblastoma (GBM) is the most aggressive primary brain tumor, with limited treatment options due to the restrictive blood-brain barrier (BBB) and the heterogeneity of the blood-tumor barrier (BTB). Temozolomide (TMZ), the standard chemotherapy, suffers from poor BBB permeability, rapid degradation,...
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Main Authors: | Lishan Cui, Giordano Perini, Antonio Minopoli, Valentina Palmieri, Marco De Spirito, Massimiliano Papi |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2025-12-01
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Series: | International Journal of Pharmaceutics: X |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S2590156725000349 |
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