Non-invasive Diagnosis of Antinephrin–Associated Podocytopathy
Introduction: Circulating autoantibodies against the podocyte surface protein nephrin have recently been described in patients with podocytopathies, that is, minimal change disease, primary focal segmental glomerulosclerosis, and childhood idiopathic nephrotic syndrome. Their high specificity for po...
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Elsevier
2025-08-01
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| Series: | Kidney International Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S246802492500292X |
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| author | Felicitas E. Hengel Michelle C.Z. Chong Wing Yin Leung Silke Dehde Anne Mühlig Matthias Janneck Henry H.L. Wu Tobias B. Huber Arvind Ponnusamy Nicola M. Tomas |
| author_facet | Felicitas E. Hengel Michelle C.Z. Chong Wing Yin Leung Silke Dehde Anne Mühlig Matthias Janneck Henry H.L. Wu Tobias B. Huber Arvind Ponnusamy Nicola M. Tomas |
| author_sort | Felicitas E. Hengel |
| collection | DOAJ |
| description | Introduction: Circulating autoantibodies against the podocyte surface protein nephrin have recently been described in patients with podocytopathies, that is, minimal change disease, primary focal segmental glomerulosclerosis, and childhood idiopathic nephrotic syndrome. Their high specificity for podocytopathies in combination with a strong correlation with disease activity hold the potential for a non-invasive diagnosis, but prospective data are lacking. Methods: Here, we describe 3 patients with contraindications or unwillingness for a kidney biopsy, hampering a timely histological diagnosis and choice of appropriate therapy. Results: In all patients, antinephrin autoantibodies were detected by quantitative immunoprecipitation, prompting the initiation of adequate treatment. These interventions induced a decrease in antinephrin autoantibody levels and clinical remission. Conclusion: Our study highlights the potential of antinephrin autoantibody measurement for a noninvasive diagnosis of antinephrin-associated podocytopathy. |
| format | Article |
| id | doaj-art-dfb054a5617b48ad9ad83d5058d2bc72 |
| institution | Matheson Library |
| issn | 2468-0249 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Kidney International Reports |
| spelling | doaj-art-dfb054a5617b48ad9ad83d5058d2bc722025-08-02T04:47:22ZengElsevierKidney International Reports2468-02492025-08-0110828002804Non-invasive Diagnosis of Antinephrin–Associated PodocytopathyFelicitas E. Hengel0Michelle C.Z. Chong1Wing Yin Leung2Silke Dehde3Anne Mühlig4Matthias Janneck5Henry H.L. Wu6Tobias B. Huber7Arvind Ponnusamy8Nicola M. Tomas9III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Hamburg Center for Kidney Health, University Medical Center Hamburg-Eppendorf, Hamburg, GermanyDepartment of Renal Medicine, Lancashire Teaching Hospitals NHS Foundation Trust, Preston, UKDepartment of Renal Medicine, Lancashire Teaching Hospitals NHS Foundation Trust, Preston, UKIII. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Hamburg Center for Kidney Health, University Medical Center Hamburg-Eppendorf, Hamburg, GermanyIII. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Hamburg Center for Kidney Health, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Department of General Internal Medicine and Nephrology, Albertinen Hospital Hamburg, Hamburg, GermanyDepartment of Pediatrics, University Medical Center Hamburg-Eppendorf, Hamburg, GermanyRenal Research, Kolling Institute of Medical Research, Royal North Shore Hospital and The University of Sydney, Sydney, New Soulth Wales, AustraliaIII. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Hamburg Center for Kidney Health, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Correspondence: Tobias B. Huber, III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, D-20246 Hamburg, Germany.Department of Renal Medicine, Lancashire Teaching Hospitals NHS Foundation Trust, Preston, UK; Faculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK; Arvind Ponnusamy, RenalDepartment, Royal Preston Hospital, PR29HT Preston, UK.III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Hamburg Center for Kidney Health, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Nicola M. Tomas, III. Department of Medicine, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, D-20246 Hamburg, Germany.Introduction: Circulating autoantibodies against the podocyte surface protein nephrin have recently been described in patients with podocytopathies, that is, minimal change disease, primary focal segmental glomerulosclerosis, and childhood idiopathic nephrotic syndrome. Their high specificity for podocytopathies in combination with a strong correlation with disease activity hold the potential for a non-invasive diagnosis, but prospective data are lacking. Methods: Here, we describe 3 patients with contraindications or unwillingness for a kidney biopsy, hampering a timely histological diagnosis and choice of appropriate therapy. Results: In all patients, antinephrin autoantibodies were detected by quantitative immunoprecipitation, prompting the initiation of adequate treatment. These interventions induced a decrease in antinephrin autoantibody levels and clinical remission. Conclusion: Our study highlights the potential of antinephrin autoantibody measurement for a noninvasive diagnosis of antinephrin-associated podocytopathy.http://www.sciencedirect.com/science/article/pii/S246802492500292Xantinephrin autoantibodiesminimal change diseasepodocytopathyserology |
| spellingShingle | Felicitas E. Hengel Michelle C.Z. Chong Wing Yin Leung Silke Dehde Anne Mühlig Matthias Janneck Henry H.L. Wu Tobias B. Huber Arvind Ponnusamy Nicola M. Tomas Non-invasive Diagnosis of Antinephrin–Associated Podocytopathy Kidney International Reports antinephrin autoantibodies minimal change disease podocytopathy serology |
| title | Non-invasive Diagnosis of Antinephrin–Associated Podocytopathy |
| title_full | Non-invasive Diagnosis of Antinephrin–Associated Podocytopathy |
| title_fullStr | Non-invasive Diagnosis of Antinephrin–Associated Podocytopathy |
| title_full_unstemmed | Non-invasive Diagnosis of Antinephrin–Associated Podocytopathy |
| title_short | Non-invasive Diagnosis of Antinephrin–Associated Podocytopathy |
| title_sort | non invasive diagnosis of antinephrin associated podocytopathy |
| topic | antinephrin autoantibodies minimal change disease podocytopathy serology |
| url | http://www.sciencedirect.com/science/article/pii/S246802492500292X |
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