Ferroptosis: A critical link to treatment resistance in esophageal carcinoma
Summary: Ferroptosis, an iron-dependent form of regulated cell death driven by lipid peroxide accumulation, induces lethal oxidative damage and disrupts cell membrane integrity. Its role in malignant tumors, such as esophageal carcinoma (EC), is increasingly recognized, offering a promising therapeu...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-07-01
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| Series: | iScience |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004225011629 |
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| author | Ming-Xin Tang Jin-Feng Chen Fa-Zhi Zhao Jun Peng |
| author_facet | Ming-Xin Tang Jin-Feng Chen Fa-Zhi Zhao Jun Peng |
| author_sort | Ming-Xin Tang |
| collection | DOAJ |
| description | Summary: Ferroptosis, an iron-dependent form of regulated cell death driven by lipid peroxide accumulation, induces lethal oxidative damage and disrupts cell membrane integrity. Its role in malignant tumors, such as esophageal carcinoma (EC), is increasingly recognized, offering a promising therapeutic avenue to overcome treatment resistance. Emerging evidence highlights the involvement of genes, proteins, the metabolism of metal ions, and tumor microenvironmental factors in modulating ferroptosis-associated resistance mechanisms in EC. This review systematically outlines current insights into ferroptosis in EC resistance and explores novel therapeutic strategies, including ferroptosis-targeted agents, nanotechnology, natural compounds, and multimodal approaches. Nevertheless, overcoming EC resistance remains a significant clinical challenge, warranting further investigation. |
| format | Article |
| id | doaj-art-df966a111a6c4a8abc3d50c63b10e61e |
| institution | Matheson Library |
| issn | 2589-0042 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj-art-df966a111a6c4a8abc3d50c63b10e61e2025-07-06T04:23:40ZengElsevieriScience2589-00422025-07-01287112901Ferroptosis: A critical link to treatment resistance in esophageal carcinomaMing-Xin Tang0Jin-Feng Chen1Fa-Zhi Zhao2Jun Peng3Department of Gastroenterology, Liyuan Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Head and Neck Surgery, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, University of Electronic Science and Technology of China, Chengdu, ChinaDepartment of Gastric Surgery, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, University of Electronic Science and Technology of China, Chengdu, China; Corresponding authorDepartment of Thoracic Surgery, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, University of Electronic Science and Technology of China, Chengdu, China; Corresponding authorSummary: Ferroptosis, an iron-dependent form of regulated cell death driven by lipid peroxide accumulation, induces lethal oxidative damage and disrupts cell membrane integrity. Its role in malignant tumors, such as esophageal carcinoma (EC), is increasingly recognized, offering a promising therapeutic avenue to overcome treatment resistance. Emerging evidence highlights the involvement of genes, proteins, the metabolism of metal ions, and tumor microenvironmental factors in modulating ferroptosis-associated resistance mechanisms in EC. This review systematically outlines current insights into ferroptosis in EC resistance and explores novel therapeutic strategies, including ferroptosis-targeted agents, nanotechnology, natural compounds, and multimodal approaches. Nevertheless, overcoming EC resistance remains a significant clinical challenge, warranting further investigation.http://www.sciencedirect.com/science/article/pii/S2589004225011629Biological sciencesCancer systems biologyHealth sciencesInternal medicineMedical specialtyMedicine |
| spellingShingle | Ming-Xin Tang Jin-Feng Chen Fa-Zhi Zhao Jun Peng Ferroptosis: A critical link to treatment resistance in esophageal carcinoma iScience Biological sciences Cancer systems biology Health sciences Internal medicine Medical specialty Medicine |
| title | Ferroptosis: A critical link to treatment resistance in esophageal carcinoma |
| title_full | Ferroptosis: A critical link to treatment resistance in esophageal carcinoma |
| title_fullStr | Ferroptosis: A critical link to treatment resistance in esophageal carcinoma |
| title_full_unstemmed | Ferroptosis: A critical link to treatment resistance in esophageal carcinoma |
| title_short | Ferroptosis: A critical link to treatment resistance in esophageal carcinoma |
| title_sort | ferroptosis a critical link to treatment resistance in esophageal carcinoma |
| topic | Biological sciences Cancer systems biology Health sciences Internal medicine Medical specialty Medicine |
| url | http://www.sciencedirect.com/science/article/pii/S2589004225011629 |
| work_keys_str_mv | AT mingxintang ferroptosisacriticallinktotreatmentresistanceinesophagealcarcinoma AT jinfengchen ferroptosisacriticallinktotreatmentresistanceinesophagealcarcinoma AT fazhizhao ferroptosisacriticallinktotreatmentresistanceinesophagealcarcinoma AT junpeng ferroptosisacriticallinktotreatmentresistanceinesophagealcarcinoma |