Study of the Activity and Toxicity of New Antibacterial Agents Based on Triindolylmethane Derivatives in vivo

Study of the Activity and Toxicity of New Antibacterial Agents Based on Triindolylmethane Derivatives in vivo

Biological properties of new synthetic triindolylmethylium antibiotics of the triindolylmethane group, including compounds containing a maleimide fragment in the structure, are studied. Their high antibacterial activity in vitro, mainly against gram-positive bacteria, but also against strains with m...

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Bibliographic Details
Main Authors: E. P. Mirchink, E. B. Isakova, S. N. Lavrenov, A. Yu. Simonov, V. A. Golibrodo, A. A. Panov, O. P. Bychkova, V. V. Tatarskiy, A. S. Trenin
Format: Article
Language:Russian
Published: LLC "Publishing House OKI" 2020-05-01
Series:Антибиотики и Химиотерапия
Subjects:
triindolylmethane
maleimide
chimeric (hybrid) antibiotics
antibacterial and antifungal activity in vitro and in vivo
cytotoxicity
in vivo toxicity
efficacy in a model of staphylococcal sepsis in mice
Online Access:https://www.antibiotics-chemotherapy.ru/jour/article/view/104
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https://www.antibiotics-chemotherapy.ru/jour/article/view/104

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