ESTIMATION OF TOXIC EFFECTS OF MEDICINAL PREPARATION OF CABAZITAXEL
A study of the toxic properties of the drug cabazitaxel was carried out on outbred rats with intravenous administration. The toxicity was assessed with a single and repeated weekly administration of the drug. It was noted that the toxic and lethal effects were delayed. In an acute experiment, the me...
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| Format: | Article |
| Language: | Russian |
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LLC Center of Pharmaceutical Analytics (LLC «CPHA»)
2019-01-01
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| Series: | Разработка и регистрация лекарственных средств |
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| Online Access: | https://www.pharmjournal.ru/jour/article/view/562 |
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| author | O. I. Avdeeva E. V. Shekunova A. A. Muzhikyan M. N. Makarova V. G. Makarov A. Ya. Hymenov |
| author_facet | O. I. Avdeeva E. V. Shekunova A. A. Muzhikyan M. N. Makarova V. G. Makarov A. Ya. Hymenov |
| author_sort | O. I. Avdeeva |
| collection | DOAJ |
| description | A study of the toxic properties of the drug cabazitaxel was carried out on outbred rats with intravenous administration. The toxicity was assessed with a single and repeated weekly administration of the drug. It was noted that the toxic and lethal effects were delayed. In an acute experiment, the mean lethal dose was calculated, which for animals of both sexes was 4.2 mg/kg. With repeated administration, the maximum tolerated dose was 1.5 mg/kg, lethal - 2.5 mg/kg. The clinical picture of intoxication was characterized by depressed behavior, decreased response to external stimuli and tonus of skeletal muscles, tachypnea and diarrhea. A decrease in feed intake and body weight of animals was detected. Target organs of toxic effect of cabazitaxel: gastrointestinal tract, liver, bone marrow, reproductive system of male rats. |
| format | Article |
| id | doaj-art-dd449b4af37e4db38c7f94f30fe28a6c |
| institution | Matheson Library |
| issn | 2305-2066 2658-5049 |
| language | Russian |
| publishDate | 2019-01-01 |
| publisher | LLC Center of Pharmaceutical Analytics (LLC «CPHA») |
| record_format | Article |
| series | Разработка и регистрация лекарственных средств |
| spelling | doaj-art-dd449b4af37e4db38c7f94f30fe28a6c2025-08-03T19:23:54ZrusLLC Center of Pharmaceutical Analytics (LLC «CPHA»)Разработка и регистрация лекарственных средств2305-20662658-50492019-01-0101174179562ESTIMATION OF TOXIC EFFECTS OF MEDICINAL PREPARATION OF CABAZITAXELO. I. Avdeeva0E. V. Shekunova1A. A. Muzhikyan2M. N. Makarova3V. G. Makarov4A. Ya. Hymenov5AO «NPO «HOUSE OF PHARMACY»AO «NPO «HOUSE OF PHARMACY»AO «NPO «HOUSE OF PHARMACY»AO «NPO «HOUSE OF PHARMACY»AO «NPO «HOUSE OF PHARMACY»«Dr. Reddy's Laboratories Ltd.» (India)A study of the toxic properties of the drug cabazitaxel was carried out on outbred rats with intravenous administration. The toxicity was assessed with a single and repeated weekly administration of the drug. It was noted that the toxic and lethal effects were delayed. In an acute experiment, the mean lethal dose was calculated, which for animals of both sexes was 4.2 mg/kg. With repeated administration, the maximum tolerated dose was 1.5 mg/kg, lethal - 2.5 mg/kg. The clinical picture of intoxication was characterized by depressed behavior, decreased response to external stimuli and tonus of skeletal muscles, tachypnea and diarrhea. A decrease in feed intake and body weight of animals was detected. Target organs of toxic effect of cabazitaxel: gastrointestinal tract, liver, bone marrow, reproductive system of male rats.https://www.pharmjournal.ru/jour/article/view/562cabazitaxeltoxicitypreclinical studiesrats |
| spellingShingle | O. I. Avdeeva E. V. Shekunova A. A. Muzhikyan M. N. Makarova V. G. Makarov A. Ya. Hymenov ESTIMATION OF TOXIC EFFECTS OF MEDICINAL PREPARATION OF CABAZITAXEL Разработка и регистрация лекарственных средств cabazitaxel toxicity preclinical studies rats |
| title | ESTIMATION OF TOXIC EFFECTS OF MEDICINAL PREPARATION OF CABAZITAXEL |
| title_full | ESTIMATION OF TOXIC EFFECTS OF MEDICINAL PREPARATION OF CABAZITAXEL |
| title_fullStr | ESTIMATION OF TOXIC EFFECTS OF MEDICINAL PREPARATION OF CABAZITAXEL |
| title_full_unstemmed | ESTIMATION OF TOXIC EFFECTS OF MEDICINAL PREPARATION OF CABAZITAXEL |
| title_short | ESTIMATION OF TOXIC EFFECTS OF MEDICINAL PREPARATION OF CABAZITAXEL |
| title_sort | estimation of toxic effects of medicinal preparation of cabazitaxel |
| topic | cabazitaxel toxicity preclinical studies rats |
| url | https://www.pharmjournal.ru/jour/article/view/562 |
| work_keys_str_mv | AT oiavdeeva estimationoftoxiceffectsofmedicinalpreparationofcabazitaxel AT evshekunova estimationoftoxiceffectsofmedicinalpreparationofcabazitaxel AT aamuzhikyan estimationoftoxiceffectsofmedicinalpreparationofcabazitaxel AT mnmakarova estimationoftoxiceffectsofmedicinalpreparationofcabazitaxel AT vgmakarov estimationoftoxiceffectsofmedicinalpreparationofcabazitaxel AT ayahymenov estimationoftoxiceffectsofmedicinalpreparationofcabazitaxel |