Separable dorsal raphe dopamine projections mimic the facets of a loneliness-like state

Separable dorsal raphe dopamine projections mimic the facets of a loneliness-like state

Affiliative social connections facilitate well-being and survival in numerous species. Engaging in social interactions requires positive or negative motivational drive, elicited through coordinated activity across neural circuits. However, the identity, interconnectivity, and functional encoding of...

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Main Authors: Christopher R Lee, Gillian A Matthews, Mackenzie E Lemieux, Elizabeth M Wasserlein, Matilde Borio, Raymundo L Miranda, Laurel R Keyes, Gates P Schneider, Caroline Jia, Andrea Tran, Faith Aloboudi, May G Chan, Enzo Peroni, Grace Pereira, Alba López-Moraga, Anna Pallé, Eyal Y Kimchi, Nancy Padilla-Coreano, Romy Wichmann, Kay M Tye
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2025-08-01
Series:eLife
Subjects:
valence
social
dorsal raphe nucleus
dopamine
amygdala
loneliness
Online Access:https://elifesciences.org/articles/105955
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https://elifesciences.org/articles/105955

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