Latency-Associated Nuclear Antigen (LANA) Promotes Ferroptosis by Suppressing Nrf2/GPX4 and Upregulating MDM2

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Latency-Associated Nuclear Antigen (LANA) Promotes Ferroptosis by Suppressing Nrf2/GPX4 and Upregulating MDM2

Ferroptosis, an iron-dependent cell death driven by lipid peroxidation, is regulated by key mediators including glutathione peroxidase 4 (GPX4) and nuclear factor erythroid 2-related factor 2 (Nrf2). Kaposi’s sarcoma-associated herpesvirus (KSHV) encodes latency-associated nuclear antigen (LANA), a...

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Bibliographic Details
Main Authors:	Yuejia Cao, Shihan Shao, Yingying Zhang, Dandan Song, Fei Gui, Xinyi Chen, Yu Hong, Rong Chen, Yang Song, Dongmei Li, Xiaohua Tan, Chunhong Di
Format:	Article
Language:	English
Published:	MDPI AG 2025-06-01
Series:	Pathogens
Subjects:	Kaposi’s sarcoma-associated herpesvirus (KSHV) latency-associated nuclear antigen (LANA) ferroptosis nuclear factor erythroid 2-related factor 2 (Nrf2) mouse-double minute 2 (MDM2)
Online Access:	https://www.mdpi.com/2076-0817/14/6/590
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