Latency-Associated Nuclear Antigen (LANA) Promotes Ferroptosis by Suppressing Nrf2/GPX4 and Upregulating MDM2

Latency-Associated Nuclear Antigen (LANA) Promotes Ferroptosis by Suppressing Nrf2/GPX4 and Upregulating MDM2

Ferroptosis, an iron-dependent cell death driven by lipid peroxidation, is regulated by key mediators including glutathione peroxidase 4 (GPX4) and nuclear factor erythroid 2-related factor 2 (Nrf2). Kaposi’s sarcoma-associated herpesvirus (KSHV) encodes latency-associated nuclear antigen (LANA), a...

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Bibliographic Details
Main Authors: Yuejia Cao, Shihan Shao, Yingying Zhang, Dandan Song, Fei Gui, Xinyi Chen, Yu Hong, Rong Chen, Yang Song, Dongmei Li, Xiaohua Tan, Chunhong Di
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Pathogens
Subjects:
Kaposi’s sarcoma-associated herpesvirus (KSHV)
latency-associated nuclear antigen (LANA)
ferroptosis
nuclear factor erythroid 2-related factor 2 (Nrf2)
mouse-double minute 2 (MDM2)
Online Access:https://www.mdpi.com/2076-0817/14/6/590
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