DISSOLUTION TEST IN QUALITY ASSESSMENT OF TABLETS CONTAINING 11-DEOXYMISOPROSTOL
Aim. Development of the dissolution test method of 11-deoxymisoprostol tablets.Materials and methods. The research was carried out on a "paddle apparatus". The media dissolution temperature is 37±0,5 degrees, the stirring rate is 50 rpm, the sampling time is 45 minutes, the dissolution med...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
Ministry of Healthcare of the Russian Federation. “Kuban State Medical University”
2018-02-01
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| Series: | Кубанский научный медицинский вестник |
| Subjects: | |
| Online Access: | https://ksma.elpub.ru/jour/article/view/1019 |
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| Summary: | Aim. Development of the dissolution test method of 11-deoxymisoprostol tablets.Materials and methods. The research was carried out on a "paddle apparatus". The media dissolution temperature is 37±0,5 degrees, the stirring rate is 50 rpm, the sampling time is 45 minutes, the dissolution media volume is 500 ml. The method of quantitative determination of 11-deoxymisoprostol in sample solution – HPLC with UV-detection, reverse phase chromatography. Chromatograph "Shimadzu Prominence LC-20" (Japan) with a matrix photodiode detector SPD20, column Discovery C18 (5 μm; 150 mm x 4.6 mm), mobile phase: water-acetonitrile (50:50), isocratic elution, detection at a wavelength of 195 nm.Results. All tested tablet samples meet the requirements of the State Pharmacopoeia in terms of "Dissolution test".Conclusion. A dissolution test method of 11-deoxyimisoprostol tablets has been developed. |
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| ISSN: | 1608-6228 2541-9544 |