Open or closed? Understanding the molecular mechanisms and clinical implications of ADAMTS13's conformation
Abstract By proteolyzing prothrombotic von Willebrand factor (VWF) multimers, ADAMTS13 (A Disintegrin And Metalloproteinase with ThromboSpondin type‐1 repeats, member 13) ensures balanced hemostasis and prevents microvascular thrombosis. ADAMTS13's conformational regulation is not only crucial...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2025-07-01
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| Series: | HemaSphere |
| Online Access: | https://doi.org/10.1002/hem3.70189 |
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