A DNA Vaccine Against Proadrenomedullin N-Terminal 20 Peptide (PAMP) Reduces Angiogenesis and Increases Lymphocyte and Macrophage Infiltration but Has No Effect on Tumor Burden in a Mouse Model of Lung Metastasis

A DNA Vaccine Against Proadrenomedullin N-Terminal 20 Peptide (PAMP) Reduces Angiogenesis and Increases Lymphocyte and Macrophage Infiltration but Has No Effect on Tumor Burden in a Mouse Model of Lung Metastasis

<b>Background/Objectives:</b> Nucleic acid-based anticancer vaccines are becoming a very active field in the fight against cancer. Here, our goal was to generate an oral DNA vaccine targeting the angiogenic peptide, proadrenomedullin N-terminal 20 peptide (PAMP). <b>Methods:</b&...

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Bibliographic Details
Main Authors: Tom Kalathil Raju, Srdan Tadic, Pablo Garrido, Laura Ochoa-Callejero, Judit Narro-Íñiguez, Josune García-Sanmartín, Alfredo Martínez
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Vaccines
Subjects:
DNA vaccine
PAMP
angiogenesis
lymphocyte infiltration
macrophages
lung metastasis model
Online Access:https://www.mdpi.com/2076-393X/13/6/586
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