The Loss of Gonadal Hormones Has a Different Impact on Aging Female and Male Mice Submitted to Heart Failure-Inducing Metabolic Hypertensive Stress

The Loss of Gonadal Hormones Has a Different Impact on Aging Female and Male Mice Submitted to Heart Failure-Inducing Metabolic Hypertensive Stress

Background: Aging and the female sex are considered risk factors for the development of heart failure with preserved ejection fraction (HFpEF). Unlike other risk factors, such as hypertension, obesity, or diabetes, they do not represent therapeutic targets. Methods: In a recently developed two-hit m...

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Bibliographic Details
Main Authors: Diwaba Carmel Teou, Emylie-Ann Labbé, Sara-Ève Thibodeau, Élisabeth Walsh-Wilkinson, Audrey Morin-Grandmont, Ann-Sarah Trudeau, Marie Arsenault, Jacques Couet
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Cells
Subjects:
mouse
heart failure
sex differences
cardiac hypertrophy
aging
preclinical model
Online Access:https://www.mdpi.com/2073-4409/14/12/870
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https://www.mdpi.com/2073-4409/14/12/870

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