Step-wise evolution of azole resistance through copy number variation followed by KSR1 loss of heterozygosity in Candida albicans.

Step-wise evolution of azole resistance through copy number variation followed by KSR1 loss of heterozygosity in Candida albicans.

Antimicrobial drug resistance poses a global health threat, requiring a deeper understanding of the evolutionary processes that lead to its emergence in pathogens. Complex evolutionary dynamics involve multiple mutations that can result in cooperative or competitive (clonal interference) effects. Ca...

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Main Authors: Pétra Vande Zande, Cécile Gautier, Nora Kawar, Corinne Maufrais, Katura Metzner, Elizabeth Wash, Annette K Beach, Ryan Bracken, Eli Isael Maciel, Nívea Pereira de Sá, Caroline Mota Fernandes, Norma V Solis, Maurizio Del Poeta, Scott G Filler, Judith Berman, Iuliana V Ene, Anna Selmecki
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2024-08-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1012497
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https://doi.org/10.1371/journal.ppat.1012497

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