Role of BMPR2 Mutation in Lung Organoid Differentiation

Role of BMPR2 Mutation in Lung Organoid Differentiation

<b>Background</b>: The bone morphogenetic protein (BMP) signaling pathway is essential for lung development. BMP4, a key regulator, binds to type I (BMPR1) and type II (BMPR2) receptors to initiate downstream signaling. While the inactivation of <i>Bmpr1a</i> and <i>Bmp...

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Bibliographic Details
Main Authors: Simin Jiang, Dian Chen, Liangliang Tian, Zihang Pan, Huanyu Long, Lanhe Chu, Weijing Kong, Qiyang Yao, Xiaojing Ma, Yun Zhao, Kai Wang, Yahong Chen
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Biomedicines
Subjects:
induced pluripotent stem cell
airway organoid
alveolar organoid
pulmonary hypertension
BMPR2
Online Access:https://www.mdpi.com/2227-9059/13/7/1623
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