Urinary Clusterin is a Biomarker of Renal Epithelial Senescence and Predicts Human Kidney Disease Progression

Urinary Clusterin is a Biomarker of Renal Epithelial Senescence and Predicts Human Kidney Disease Progression

Introduction: Cellular senescence is characterized by generally irreversible cell cycle arrest and changes in secretory activity, with senescent renal epithelia proposed as drivers of kidney fibrosis. The lack of noninvasive biomarkers represents an obstacle to the design of human trials of senescen...

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Main Authors: David P. Baird, Maximilian Reck, Ross Campbell, Marie-Helena Docherty, Piotr P. Janas, Tilly Mason, Zenuida Mortuza, Matthieu Vermeren, Andy Nam, Wei Yang, Nathan Schurman, Claire Williams, Jamie P. Traynor, Patrick B. Mark, Katie J. Mylonas, Jeremy Hughes, Laura Denby, Bryan R. Conway, David A. Ferenbach
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:Kidney International Reports
Subjects:
aging
biomarkers
cellular senescence
chronic kidney disease
clusterin
fibrosis
Online Access:http://www.sciencedirect.com/science/article/pii/S2468024925002608
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http://www.sciencedirect.com/science/article/pii/S2468024925002608

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