Lung-resident SARS-CoV-2 peptide-specific immune responses in perfused 3D human lung explant models

Lung-resident SARS-CoV-2 peptide-specific immune responses in perfused 3D human lung explant models

IntroductionMulti-specific and long-lasting T-cell immunity has been recognized to indicate long-term protection against pathogens, including the novel coronavirus, SARS-CoV-2, which is the causative agent of the COVID-19 pandemic. Functional significance of peripheral memory T cells in individuals...

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Main Authors: Kayla F. Goliwas, Anthony M. Wood, Christopher S. Simmons, Rabisa Khan, Saad A. Khan, Yong Wang, Rekha Ramachandran, Joel L. Berry, Mohammad Athar, James A. Mobley, Young-il Kim, Victor J. Thannickal, Kevin S. Harrod, James M. Donahue, Jessy S. Deshane
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
human lung-tissue model
SARS-CoV-2 infection
COVID-19
perfused lung explant
local antiviral immune response
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2025.1587080/full
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https://www.frontiersin.org/articles/10.3389/fbioe.2025.1587080/full

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