Gypensapogenin I alleviates PANoptosis, ferroptosis, and oxidative stress in myocardial ischemic–reperfusion injury by targeting the NOX2/AMPK pathway

Gypensapogenin I alleviates PANoptosis, ferroptosis, and oxidative stress in myocardial ischemic–reperfusion injury by targeting the NOX2/AMPK pathway

AimThis study aims to investigate the benefits of gypensapogenin I (GI) on myocardial ischemia–reperfusion injury (MIRI) and the underlying mechanisms.MethodsAn MIRI model was established by ligating the anterior descending coronary artery (LAD) followed by blood flow restoration in mice. Cardiac dy...

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Bibliographic Details
Main Authors: Yuqiong Chen, Bo Guan, Jian Lu, Xiaopei Yan, Chao Huang, Yuli Qiu, Xinyan Li, Xiangyu Sun, Lin Chen, Wei Li, Wenjun Mao, Zhongqi Sun, Bin Xu, Su Li, Chao Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
gypensapogenin I
myocardial ischemia–reperfusion injury
PANoptosis
ferroptosis
oxidative stress
NADPH oxidase 2
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2025.1623846/full
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