Temporal Lobe Epilepsy Perturbs the Brain‐Wide Excitation‐Inhibition Balance: Associations with Microcircuit Organization, Clinical Parameters, and Cognitive Dysfunction

Temporal Lobe Epilepsy Perturbs the Brain‐Wide Excitation‐Inhibition Balance: Associations with Microcircuit Organization, Clinical Parameters, and Cognitive Dysfunction

Abstract Excitation‐inhibition (E/I) imbalance is theorized as a key mechanism in the pathophysiology of epilepsy, with ample research focusing on elucidating its cellular manifestations. However, few studies investigate E/I imbalance at the macroscale, whole‐brain level, and its microcircuit‐level...

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Main Authors: Ke Xie, Jessica Royer, Raul Rodriguez‐Cruces, Linda Horwood, Alexander Ngo, Thaera Arafat, Hans Auer, Ella Sahlas, Judy Chen, Yigu Zhou, Sofie L. Valk, Seok‐Jun Hong, Birgit Frauscher, Raluca Pana, Andrea Bernasconi, Neda Bernasconi, Luis Concha, Boris C. Bernhardt
Format: Article
Language:English
Published: Wiley 2025-03-01
Series:Advanced Science
Subjects:
cognitive impairment
excitation/inhibition imbalance
microcircuit perturbation
multimodal MRI
temporal lobe epilepsy
Online Access:https://doi.org/10.1002/advs.202406835
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https://doi.org/10.1002/advs.202406835

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