Human brain single-cell data reveal shared synaptic dysfunction and immune abnormality in epilepsy and Alzheimer′s disease
Objective To identify co-expressed genes and potential comorbidity mechanisms between Alzheimer′s disease(AD) and epilepsy with publicly available single-cell transcriptome sequencing data from human brains, followed by functional validation in APP/PS1 double transgenic AD mouse models expressing th...
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| Main Author: | |
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| Format: | Article |
| Language: | Chinese |
| Published: |
Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College.
2025-07-01
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| Series: | Jichu yixue yu linchuang |
| Subjects: | |
| Online Access: | https://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/1001-6325-2025-45-7-841.pdf |
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