Opposing regulation of TNF responses by IFN-γ and a PGE2-cAMP axis that is apparent in rheumatoid and immune checkpoint inhibitor-induced arthritis human IL-1β+ macrophages

Opposing regulation of TNF responses by IFN-γ and a PGE2-cAMP axis that is apparent in rheumatoid and immune checkpoint inhibitor-induced arthritis human IL-1β+ macrophages

IL-1β-expressing macrophages have been described in rheumatoid arthritis (RA), immune checkpoint inhibitor-induced inflammatory arthritis (ICI-arthritis), and pancreatic cancer and proposed to be pathogenic. IL-1β+ macrophages express genes cooperatively induced by PGE2 and TNF signaling, but mechan...

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Bibliographic Details
Main Authors: Upneet K Sokhi, Ruoxi Yuan, Bikash Mishra, Yurii Chinenov, Anvita Singaraju, Karmela K Chan, Anne Bass, Richard D Bell, Laura Donlin, Lionel B Ivashkiv
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2025-07-01
Series:eLife
Subjects:
macrophages
inflammation
tumor necrosis factor
interferon gamma
immune checkpoint inhibition
rheumatoid arthritis
Online Access:https://elifesciences.org/articles/104367
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https://elifesciences.org/articles/104367

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